Systems Microbiology: Current Topics and Applications (Hardcover)

Description

Systems biology examines how multiple components interact dynamically to shape the behavior of a biological system. In microbiology, that systems-level lens becomes especially powerful because single-cell organisms are experimentally tractable and increasingly measurable in the “omics era.” This volume brings together cutting-edge reviews by leading experts who map the tools, concepts, and real-world case studies that define modern systems microbiology.

Rather than treating microbes as a list of parts, the book emphasizes frameworks that connect data, models, and mechanism. It covers foundational approaches in mathematical modeling and then applies systems thinking across key microbial phenomena, from metabolic network behavior and bacterial chemotaxis to infection biology, host–microbe interactions, and phagocytosis. The result is a focused reference for readers who want a coherent view of how system-level methods are actually used in contemporary microbiology research.

Topics include

• Mathematical models for systems biology and how to construct them

• Systems views of metabolism (including E. coli and network robustness)

• Bacterial chemotaxis and increasing pathway complexity

• Systems biology of infection and pathogen-centered perspectives

• Host–pathogen interaction strategies and immune-relevant processes

• Phagocytosis principles as a multi-component cellular system

• System-level metabolism study in Mycobacterium tuberculosis

• Systems biology of Sulfolobus and high-temperature metabolic design