HIV Chemotherapy: A Critical Review (Hardcover)

Description

HIV Chemotherapy: A Critical Review is a focused scientific volume examining why modern antiretroviral therapy has transformed HIV into a manageable chronic infection for many patients, yet still falls short of eradication. The book emphasizes the practical scientific challenges that continue to shape HIV treatment: lifelong dependence on largely virostatic regimens, clinically significant adverse effects, and the ongoing emergence of drug-resistant viral variants driven by HIV’s genetic diversity.

Edited by Salvatore T. Butera and introduced by Robert T. Schooley, this hardback reference brings together expert contributors to evaluate therapeutic strategies across the infection lifecycle and the host–virus interface. Coverage spans clinical management considerations, the genetics and mechanisms of resistance, drug-resistance testing technologies, and the rationale behind next-generation approaches designed to improve potency, durability, and tolerability.

Particular attention is given to molecularly informed interventions, including strategies aimed at strengthening host immune function, identifying and exploiting novel viral and cellular targets, and addressing persistent reservoirs that complicate definitive cure. The book also considers implementation realities in resource-limited regions where the burden of HIV has historically been greatest, framing chemotherapy and public health strategy as inseparable components of effective control.

Designed for scientists and advanced readers working in HIV/AIDS and retrovirology, this volume functions as a rigorous, curated “state of the field” reference for laboratories, clinicians engaged with the research literature, and academic health collections.